D57 — Sickle-cell disorders
Is D57 billable?
No — D57 is a non-billable header code. D57 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 43 billable codes beneath D57.
Billable codes under this header
- D57.1Sickle-cell disease without crisis
- D57.3Sickle-cell trait
- D57.00Hb-SS disease with crisis, unspecified
- D57.01Hb-SS disease with acute chest syndrome
- D57.02Hb-SS disease with splenic sequestration
- D57.03Hb-SS disease with cerebral vascular involvement
- D57.04Hb-SS disease with dactylitis
- D57.09Hb-SS disease with crisis with other specified complication
- D57.20Sickle-cell/Hb-C disease without crisis
- D57.40Sickle-cell thalassemia without crisis
- D57.42Sickle-cell thalassemia beta zero without crisis
- D57.44Sickle-cell thalassemia beta plus without crisis
- D57.80Other sickle-cell disorders without crisis
- D57.211Sickle-cell/Hb-C disease with acute chest syndrome
- D57.212Sickle-cell/Hb-C disease with splenic sequestration
- D57.213Sickle-cell/Hb-C disease with cerebral vascular involvement
- D57.214Sickle-cell/Hb-C disease with dactylitis
- D57.218Sickle-cell/Hb-C disease with crisis with other specified complication
- D57.219Sickle-cell/Hb-C disease with crisis, unspecified
- D57.411Sickle-cell thalassemia, unspecified, with acute chest syndrome
- D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration
- D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
- D57.414Sickle-cell thalassemia, unspecified, with dactylitis
- D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
- D57.419Sickle-cell thalassemia, unspecified, with crisis
- D57.431Sickle-cell thalassemia beta zero with acute chest syndrome
- D57.432Sickle-cell thalassemia beta zero with splenic sequestration
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvement
- D57.434Sickle-cell thalassemia beta zero with dactylitis
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complication
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecified
- D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
- D57.452Sickle-cell thalassemia beta plus with splenic sequestration
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
- D57.454Sickle-cell thalassemia beta plus with dactylitis
- D57.458Sickle-cell thalassemia beta plus with crisis with other specified complication
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecified
- D57.811Other sickle-cell disorders with acute chest syndrome
- D57.812Other sickle-cell disorders with splenic sequestration
- D57.813Other sickle-cell disorders with cerebral vascular involvement
- D57.814Other sickle-cell disorders with dactylitis
- D57.818Other sickle-cell disorders with crisis with other specified complication
- D57.819Other sickle-cell disorders with crisis, unspecified
D57 at a glance
| Code | D57 |
|---|---|
| Description | Sickle-cell disorders |
| Billable | No — header code |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
How is D57 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to D57. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Arthropathy › gouty › in › sickle-cell disorders
Excludes1 — never code together
The conditions below can never be reported together with D57 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- other hemoglobinopathies (D58.-)
Use additional code
Report an additional code alongside D57 to fully describe the condition. D57 is sequenced first.
- code for any associated fever (R50.81)
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D57, but a patient may have both at the same time. When documentation supports it, D57 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
What codes fall under D57? (6)
How long has D57 existed?
D57 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
Which codes are confused with D57?
ICD-10-CM declares these codes mutually exclusive with D57 — exactly one of each pair can be correct for a given encounter.