D57.458 — Sickle-cell thalassemia beta plus with crisis with other specified complication
Is D57.458 billable?
Yes, but D57.458 is an unspecified code. D57.458 is a valid, billable ICD-10-CM code for encounters from October 1, 2026 through September 30, 2027. However, D57.458 is an unspecified or catch-all code. Payers apply additional scrutiny to unspecified codes and many deny them when the medical record supports a more specific option, so check the documentation before selecting D57.458 — the more specific alternatives are listed below.
D57.458 at a glance
| Code | D57.458 |
|---|---|
| Description | Sickle-cell thalassemia beta plus with crisis with other specified complication |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Which MS-DRGs does D57.458 group to?
D57.458 sits in MDC 15 and helps define the logic of 1 MS-DRG (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 791Prematurity with Major Problemsmedical
As a secondary diagnosis, D57.458 is a major complication or comorbidity (MCC), which can move a stay into a higher-paying DRG.
How is D57.458 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to D57.458. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Disease, diseased › sickle-cell › thalassemia › beta plus › with › priapism
- Disease, diseased › sickle-cell › thalassemia › beta plus › with › crisis › with specified complication NEC
- Disease, diseased › hemoglobin or Hb › S or SS › beta plus › with › crisis › with › specified complication
Use additional code
Report an additional code alongside D57.458 to fully describe the condition. D57.458 is sequenced first.
Inclusion terms
Alternative wording in documentation that is classified to D57.458.
- HbS-beta plus with crisis with other specified complication
- Sickle-cell beta plus with crisis with other specified complication
Excludes1 — never code together — inherited from D57
The conditions below can never be reported together with D57.458 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- other hemoglobinopathies (D58.-)
Use additional code — inherited from D57
Report an additional code alongside D57.458 to fully describe the condition. D57.458 is sequenced first.
- code for any associated fever (R50.81)
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D57.458, but a patient may have both at the same time. When documentation supports it, D57.458 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
How long has D57.458 existed?
D57.458 first appears in FY2021 (FY2020 is not available, so it may have appeared then).
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
What other codes are in the D57.45 family? (5)
- D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
- D57.452Sickle-cell thalassemia beta plus with splenic sequestration
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
- D57.454Sickle-cell thalassemia beta plus with dactylitis
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecified