E88 — Other and unspecified metabolic disorders
Is E88 billable?
No — E88 is a non-billable header code. E88 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 24 billable codes beneath E88.
Billable codes under this header
- E88.2Lipomatosis, not elsewhere classified
- E88.3Tumor lysis syndrome
- E88.9Metabolic disorder, unspecified
- E88.AWasting disease (syndrome) due to underlying condition
- E88.01Alpha-1-antitrypsin deficiency
- E88.02Plasminogen deficiency
- E88.09Other disorders of plasma-protein metabolism, not elsewhere classified
- E88.10Lipodystrophy, unspecified
- E88.11Partial lipodystrophy
- E88.12Generalized lipodystrophy
- E88.13Localized lipodystrophy
- E88.14HIV-associated lipodystrophy
- E88.19Other lipodystrophy, not elsewhere classified
- E88.40Mitochondrial metabolism disorder, unspecified
- E88.41MELAS syndrome
- E88.42MERRF syndrome
- E88.43Disorders of mitochondrial tRNA synthetases
- E88.49Other mitochondrial metabolism disorders
- E88.82Obesity due to disruption of MC4R pathway
- E88.89Other specified metabolic disorders
- E88.810Metabolic syndrome
- E88.811Insulin resistance syndrome, Type A
- E88.818Other insulin resistance
- E88.819Insulin resistance, unspecified
E88 at a glance
| Code | E88 |
|---|---|
| Description | Other and unspecified metabolic disorders |
| Billable | No — header code |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Excludes1 — never code together
The conditions below can never be reported together with E88 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- histiocytosis X (chronic) (C96.6)
Use additional code
Report an additional code alongside E88 to fully describe the condition. E88 is sequenced first.
- codes for associated conditions
Excludes1 — never code together — inherited from Chapter 4
The conditions below can never be reported together with E88 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Excludes1 — never code together — inherited from E70-E88
The conditions below can never be reported together with E88 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes2 — not included here — inherited from E70-E88
The conditions below are not part of E88, but a patient may have both at the same time. When documentation supports it, E88 and the excluded code may both be reported.
- Ehlers-Danlos syndromes (Q79.6-)
What codes fall under E88? (8)
- E88.0Disorders of plasma-protein metabolism, not elsewhere classifiednot billable
- E88.1Lipodystrophy, not elsewhere classifiednot billable
- E88.2Lipomatosis, not elsewhere classified
- E88.3Tumor lysis syndrome
- E88.4Mitochondrial metabolism disordersnot billable
- E88.8Other specified metabolic disordersnot billable
- E88.9Metabolic disorder, unspecified
- E88.AWasting disease (syndrome) due to underlying condition
How long has E88 existed?
E88 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
Which codes are confused with E88?
ICD-10-CM declares these codes mutually exclusive with E88 — exactly one of each pair can be correct for a given encounter.