D57.4 — Sickle-cell thalassemia
Is D57.4 billable?
No — D57.4 is a non-billable header code. D57.4 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 21 billable codes beneath D57.4.
Billable codes under this header
- D57.40Sickle-cell thalassemia without crisis
- D57.42Sickle-cell thalassemia beta zero without crisis
- D57.44Sickle-cell thalassemia beta plus without crisis
- D57.411Sickle-cell thalassemia, unspecified, with acute chest syndrome
- D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration
- D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
- D57.414Sickle-cell thalassemia, unspecified, with dactylitis
- D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
- D57.419Sickle-cell thalassemia, unspecified, with crisis
- D57.431Sickle-cell thalassemia beta zero with acute chest syndrome
- D57.432Sickle-cell thalassemia beta zero with splenic sequestration
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvement
- D57.434Sickle-cell thalassemia beta zero with dactylitis
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complication
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecified
- D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
- D57.452Sickle-cell thalassemia beta plus with splenic sequestration
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
- D57.454Sickle-cell thalassemia beta plus with dactylitis
- D57.458Sickle-cell thalassemia beta plus with crisis with other specified complication
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecified
D57.4 at a glance
| Code | D57.4 |
|---|---|
| Description | Sickle-cell thalassemia |
| Billable | No — header code |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
How is D57.4 listed in the Alphabetic Index?
The Alphabetic Index lists these routes under D57, the nearest indexed parent of D57.4. Use them to find the family, then select the specific code.
- Arthropathy › gouty › in › sickle-cell disorders
Inclusion terms
Alternative wording in documentation that is classified to D57.4.
- Sickle-cell beta thalassemia
- Thalassemia Hb-S disease
Excludes1 — never code together — inherited from D57
The conditions below can never be reported together with D57.4 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- other hemoglobinopathies (D58.-)
Use additional code — inherited from D57
Report an additional code alongside D57.4 to fully describe the condition. D57.4 is sequenced first.
- code for any associated fever (R50.81)
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D57.4, but a patient may have both at the same time. When documentation supports it, D57.4 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
What codes fall under D57.4? (6)
- D57.40Sickle-cell thalassemia without crisis
- D57.41Sickle-cell thalassemia, unspecified, with crisisnot billable
- D57.42Sickle-cell thalassemia beta zero without crisis
- D57.43Sickle-cell thalassemia beta zero with crisisnot billable
- D57.44Sickle-cell thalassemia beta plus without crisis
- D57.45Sickle-cell thalassemia beta plus with crisisnot billable
How long has D57.4 existed?
D57.4 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.