ICDcodes.org
FY2027

D57.412 — Sickle-cell thalassemia, unspecified, with splenic sequestration

BillableUnspecifiedMCC

Is D57.412 billable?

Yes, but D57.412 is an unspecified code. D57.412 is a valid, billable ICD-10-CM code for encounters from October 1, 2026 through September 30, 2027. However, D57.412 is an unspecified or catch-all code. Payers apply additional scrutiny to unspecified codes and many deny them when the medical record supports a more specific option, so check the documentation before selecting D57.412 — the more specific alternatives are listed below.

D57.412 at a glance

CodeD57.412
DescriptionSickle-cell thalassemia, unspecified, with splenic sequestration
BillableYes
Code setICD-10-CM FY2027
Valid for encountersOctober 1, 2026 – September 30, 2027

Which MS-DRGs does D57.412 group to?

D57.412 sits in MDC 15 and helps define the logic of 1 MS-DRG (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.

  • 791Prematurity with Major Problemsmedical

As a secondary diagnosis, D57.412 is a major complication or comorbidity (MCC), which can move a stay into a higher-paying DRG.

How is D57.412 listed in the Alphabetic Index?

These are the routes through the Alphabetic Index that lead to D57.412. They show the wording a clinician may have documented, which often differs from the Tabular description.

  • Microdrepanocytosis › with › splenic sequestration
  • Disease, diseased › sickle-cell › thalassemia › with › splenic sequestration
  • Hemoglobinopathy › sickle-cell › with thalassemia › with › splenic sequestration (mixed)

Excludes1 — never code together — inherited from D57

The conditions below can never be reported together with D57.412 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

  • other hemoglobinopathies (D58.-)

Use additional code — inherited from D57

Report an additional code alongside D57.412 to fully describe the condition. D57.412 is sequenced first.

  • code for any associated fever (R50.81)

Excludes2 — not included here — inherited from Chapter 3

The conditions below are not part of D57.412, but a patient may have both at the same time. When documentation supports it, D57.412 and the excluded code may both be reported.

  • autoimmune disease (systemic) NOS (M35.9)
  • certain conditions originating in the perinatal period (P00-P96)
  • complications of pregnancy, childbirth and the puerperium (O00-O9A)
  • congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
  • endocrine, nutritional and metabolic diseases (E00-E88)
  • human immunodeficiency virus [HIV] disease (B20)
  • injury, poisoning and certain other consequences of external causes (S00-T88)
  • neoplasms (C00-D49)
  • symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

How long has D57.412 existed?

D57.412 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.

Description changes
  • FY2021
    Sickle-cell thalassemia with splenic sequestration
    Sickle-cell thalassemia, unspecified, with splenic sequestration

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.

Which conditions are coded to D57.412?

What other codes are in the D57.41 family? (5)