D57.00 — Hb-SS disease with crisis, unspecified
Is D57.00 billable?
Yes, but D57.00 is an unspecified code. D57.00 is a valid, billable ICD-10-CM code for encounters from October 1, 2026 through September 30, 2027. However, D57.00 is an unspecified or catch-all code. Payers apply additional scrutiny to unspecified codes and many deny them when the medical record supports a more specific option, so check the documentation before selecting D57.00 — the more specific alternatives are listed below.
D57.00 at a glance
| Code | D57.00 |
|---|---|
| Description | Hb-SS disease with crisis, unspecified |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Which MS-DRGs does D57.00 group to?
D57.00 sits in MDC 16 and helps define the logic of 2 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 811Red Blood Cell Disorders with MCCmedical
- 812Red Blood Cell Disorders without MCCmedical
As a secondary diagnosis, D57.00 is a major complication or comorbidity (MCC), which can move a stay into a higher-paying DRG.
How is D57.00 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to D57.00. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Crisis › sickle-cell
- Crisis › sickle-cell › with › pain
- Disease, diseased › sickle-cell › with › crisis
- Disease, diseased › sickle-cell › with › pain
- Disease, diseased › hemoglobin or Hb › S or SS › with › crisis
- Disease, diseased › hemoglobin or Hb › S or SS › with › pain
Inclusion terms
Alternative wording in documentation that is classified to D57.00.
- Hb-SS disease with (painful) crisis NOS
- Hb-SS disease with (vaso-occlusive) pain NOS
Excludes1 — never code together — inherited from D57
The conditions below can never be reported together with D57.00 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- other hemoglobinopathies (D58.-)
Use additional code — inherited from D57
Report an additional code alongside D57.00 to fully describe the condition. D57.00 is sequenced first.
- code for any associated fever (R50.81)
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D57.00, but a patient may have both at the same time. When documentation supports it, D57.00 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
How long has D57.00 existed?
D57.00 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.