D57.40 — Sickle-cell thalassemia without crisis

Billable

Is D57.40 billable?

Yes — D57.40 is billable for FY2027. D57.40 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. D57.40 may be submitted for encounters from October 1, 2026 through September 30, 2027.

D57.40 at a glance

Code	D57.40
Description	Sickle-cell thalassemia without crisis
Billable	Yes
Code set	ICD-10-CM FY2027
Valid for encounters	October 1, 2026 – September 30, 2027

Which MS-DRGs does D57.40 group to?

D57.40 sits in MDC 15 and helps define the logic of 1 MS-DRG (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.

791Prematurity with Major Problemsmedical

How is D57.40 listed in the Alphabetic Index?

These are the routes through the Alphabetic Index that lead to D57.40. They show the wording a clinician may have documented, which often differs from the Tabular description.

Microdrepanocytosis
Anemia › microdrepanocytosis (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
Disease, diseased › sickle-cell › thalassemia
Hemoglobinopathy › sickle-cell › with thalassemia (mixed)
Disease, diseased › sickle-cell › thalassemia › without crisis
Hemoglobinopathy › sickle-cell › with thalassemia › without crisis (mixed)

Inclusion terms

Alternative wording in documentation that is classified to D57.40.

Microdrepanocytosis
Sickle-cell thalassemia NOS

Excludes1 — never code together — inherited from D57

The conditions below can never be reported together with D57.40 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

other hemoglobinopathies (D58.-)

Use additional code — inherited from D57

Report an additional code alongside D57.40 to fully describe the condition. D57.40 is sequenced first.

code for any associated fever (R50.81)

Excludes2 — not included here — inherited from Chapter 3

The conditions below are not part of D57.40, but a patient may have both at the same time. When documentation supports it, D57.40 and the excluded code may both be reported.

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

How long has D57.40 existed?

D57.40 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.