D57.431 — Sickle-cell thalassemia beta zero with acute chest syndrome

BillableMCC

Is D57.431 billable?

Yes — D57.431 is billable for FY2027. D57.431 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. D57.431 may be submitted for encounters from October 1, 2026 through September 30, 2027.

D57.431 at a glance

Code	D57.431
Description	Sickle-cell thalassemia beta zero with acute chest syndrome
Billable	Yes
Code set	ICD-10-CM FY2027
Valid for encounters	October 1, 2026 – September 30, 2027

Which MS-DRGs does D57.431 group to?

D57.431 sits in MDC 15 and helps define the logic of 1 MS-DRG (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.

791Prematurity with Major Problemsmedical

As a secondary diagnosis, D57.431 is a major complication or comorbidity (MCC), which can move a stay into a higher-paying DRG.

How is D57.431 listed in the Alphabetic Index?

These are the routes through the Alphabetic Index that lead to D57.431. They show the wording a clinician may have documented, which often differs from the Tabular description.

Disease, diseased › hemoglobin or Hb › S or SS › beta zero › with › acute chest syndrome
Disease, diseased › sickle-cell › thalassemia › beta zero › with › acute chest syndrome

Inclusion terms

Alternative wording in documentation that is classified to D57.431.

HbS-beta zero with acute chest syndrome
Sickle-cell beta zero with acute chest syndrome

Excludes1 — never code together — inherited from D57

The conditions below can never be reported together with D57.431 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

other hemoglobinopathies (D58.-)

Use additional code — inherited from D57

Report an additional code alongside D57.431 to fully describe the condition. D57.431 is sequenced first.

code for any associated fever (R50.81)

Excludes2 — not included here — inherited from Chapter 3

The conditions below are not part of D57.431, but a patient may have both at the same time. When documentation supports it, D57.431 and the excluded code may both be reported.

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

How long has D57.431 existed?

D57.431 first appears in FY2021 (FY2020 is not available, so it may have appeared then).

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.