D57.453 — Sickle-cell thalassemia beta plus with cerebral vascular involvement

BillableMCC

Is D57.453 billable?

Yes — D57.453 is billable for FY2027. D57.453 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. D57.453 may be submitted for encounters from October 1, 2026 through September 30, 2027.

D57.453 at a glance

Code	D57.453
Description	Sickle-cell thalassemia beta plus with cerebral vascular involvement
Billable	Yes
Code set	ICD-10-CM FY2027
Valid for encounters	October 1, 2026 – September 30, 2027

Which MS-DRGs does D57.453 group to?

D57.453 sits in MDC 15 and helps define the logic of 1 MS-DRG (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.

791Prematurity with Major Problemsmedical

As a secondary diagnosis, D57.453 is a major complication or comorbidity (MCC), which can move a stay into a higher-paying DRG.

How is D57.453 listed in the Alphabetic Index?

These are the routes through the Alphabetic Index that lead to D57.453. They show the wording a clinician may have documented, which often differs from the Tabular description.

Disease, diseased › hemoglobin or Hb › S or SS › beta plus › with › cerebral vascular involvement
Disease, diseased › sickle-cell › thalassemia › beta plus › with › cerebral vascular involvement

Code also

Two codes may be needed to describe the condition fully. Whether D57.453 is sequenced first depends on the reason for the encounter.

, if applicable cerebral infarction (I63.-)

Inclusion terms

Alternative wording in documentation that is classified to D57.453.

HbS-beta plus with cerebral vascular involvement
Sickle-cell beta plus with cerebral vascular involvement

Excludes1 — never code together — inherited from D57

The conditions below can never be reported together with D57.453 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

other hemoglobinopathies (D58.-)

Use additional code — inherited from D57

Report an additional code alongside D57.453 to fully describe the condition. D57.453 is sequenced first.

code for any associated fever (R50.81)

Excludes2 — not included here — inherited from Chapter 3

The conditions below are not part of D57.453, but a patient may have both at the same time. When documentation supports it, D57.453 and the excluded code may both be reported.

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

How long has D57.453 existed?

D57.453 first appears in FY2021 (FY2020 is not available, so it may have appeared then).

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.