D57.454 — Sickle-cell thalassemia beta plus with dactylitis

BillableMCC

Is D57.454 billable?

Yes — D57.454 is billable for FY2027. D57.454 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. D57.454 may be submitted for encounters from October 1, 2026 through September 30, 2027.

D57.454 at a glance

Code	D57.454
Description	Sickle-cell thalassemia beta plus with dactylitis
Billable	Yes
Code set	ICD-10-CM FY2027
Valid for encounters	October 1, 2026 – September 30, 2027

Which MS-DRGs does D57.454 group to?

D57.454 sits in MDC 15 and helps define the logic of 1 MS-DRG (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.

791Prematurity with Major Problemsmedical

As a secondary diagnosis, D57.454 is a major complication or comorbidity (MCC), which can move a stay into a higher-paying DRG.

How is D57.454 listed in the Alphabetic Index?

These are the routes through the Alphabetic Index that lead to D57.454. They show the wording a clinician may have documented, which often differs from the Tabular description.

Dactylitis › sickle-cell › Beta plus
Disease, diseased › sickle-cell › thalassemia › beta plus › with › dactylitis
Disease, diseased › sickle-cell › thalassemia › beta plus › with › acute chest syndrome › with dactylitis
Disease, diseased › hemoglobin or Hb › S or SS › beta plus › with › crisis › with › dactylitis

Excludes1 — never code together — inherited from D57

The conditions below can never be reported together with D57.454 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

other hemoglobinopathies (D58.-)

Use additional code — inherited from D57

Report an additional code alongside D57.454 to fully describe the condition. D57.454 is sequenced first.

code for any associated fever (R50.81)

Excludes2 — not included here — inherited from Chapter 3

The conditions below are not part of D57.454, but a patient may have both at the same time. When documentation supports it, D57.454 and the excluded code may both be reported.

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

How long has D57.454 existed?

D57.454 first appears in FY2024.

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.