D57.418 — Sickle-cell thalassemia, unspecified, with crisis with other specified complication

BillableUnspecifiedMCC

Is D57.418 billable?

Yes, but D57.418 is an unspecified code. D57.418 is a valid, billable ICD-10-CM code for encounters from October 1, 2026 through September 30, 2027. However, D57.418 is an unspecified or catch-all code. Payers apply additional scrutiny to unspecified codes and many deny them when the medical record supports a more specific option, so check the documentation before selecting D57.418 — the more specific alternatives are listed below.

More specific alternatives

D57.418 at a glance

Code	D57.418
Description	Sickle-cell thalassemia, unspecified, with crisis with other specified complication
Billable	Yes
Code set	ICD-10-CM FY2027
Valid for encounters	October 1, 2026 – September 30, 2027

Which MS-DRGs does D57.418 group to?

D57.418 sits in MDC 15 and helps define the logic of 1 MS-DRG (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.

791Prematurity with Major Problemsmedical

As a secondary diagnosis, D57.418 is a major complication or comorbidity (MCC), which can move a stay into a higher-paying DRG.

How is D57.418 listed in the Alphabetic Index?

These are the routes through the Alphabetic Index that lead to D57.418. They show the wording a clinician may have documented, which often differs from the Tabular description.

Microdrepanocytosis › with › crisis › with specified complication NEC
Disease, diseased › sickle-cell › thalassemia › with › priapism
Disease, diseased › sickle-cell › thalassemia › with › acute chest syndrome › with specified complication NEC
Disease, diseased › sickle-cell › thalassemia › with › crisis › with specified complication NEC
Hemoglobinopathy › sickle-cell › with thalassemia › with › crisis › with › specified complication NEC (mixed)

Use additional code

Report an additional code alongside D57.418 to fully describe the condition. D57.418 is sequenced first.

code to identify complications, such as:
cholelithiasis (K80.-)
priapism (N48.32)

Excludes1 — never code together — inherited from D57

The conditions below can never be reported together with D57.418 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

other hemoglobinopathies (D58.-)

Use additional code — inherited from D57

Report an additional code alongside D57.418 to fully describe the condition. D57.418 is sequenced first.

code for any associated fever (R50.81)

Excludes2 — not included here — inherited from Chapter 3

The conditions below are not part of D57.418, but a patient may have both at the same time. When documentation supports it, D57.418 and the excluded code may both be reported.

autoimmune disease (systemic) NOS (M35.9)
certain conditions originating in the perinatal period (P00-P96)
complications of pregnancy, childbirth and the puerperium (O00-O9A)
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
endocrine, nutritional and metabolic diseases (E00-E88)
human immunodeficiency virus [HIV] disease (B20)
injury, poisoning and certain other consequences of external causes (S00-T88)
neoplasms (C00-D49)
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)

How long has D57.418 existed?

D57.418 first appears in FY2021 (FY2020 is not available, so it may have appeared then).

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.