ICDcodes.org
FY2027

E88.3 — Tumor lysis syndrome

BillableMCC

Is E88.3 billable?

Yes — E88.3 is billable for FY2027. E88.3 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. E88.3 may be submitted for encounters from October 1, 2026 through September 30, 2027.

E88.3 at a glance

CodeE88.3
DescriptionTumor lysis syndrome
BillableYes
Code setICD-10-CM FY2027
Valid for encountersOctober 1, 2026 – September 30, 2027

Which MS-DRGs does E88.3 group to?

E88.3 sits in MDC 11 and helps define the logic of 3 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.

  • 673Other Kidney and Urinary Tract Procedures with MCCsurgical
  • 674Other Kidney and Urinary Tract Procedures with CCsurgical
  • 675Other Kidney and Urinary Tract Procedures without CC/MCCsurgical

As a secondary diagnosis, E88.3 is a major complication or comorbidity (MCC), which can move a stay into a higher-paying DRG.

How is E88.3 listed in the Alphabetic Index?

These are the routes through the Alphabetic Index that lead to E88.3. They show the wording a clinician may have documented, which often differs from the Tabular description.

  • Tumor lysis syndromeNEC (following antineoplastic chemotherapy) (spontaneous)
  • Syndrome › tumor lysisNEC

Use additional code

Report an additional code alongside E88.3 to fully describe the condition. E88.3 is sequenced first.

  • code for adverse effect, if applicable, to identify drug (T45.1X5)

Inclusion terms

Alternative wording in documentation that is classified to E88.3.

  • Tumor lysis syndrome (spontaneous)
  • Tumor lysis syndrome following antineoplastic drug chemotherapy

Excludes1 — never code together — inherited from Chapter 4

The conditions below can never be reported together with E88.3 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)

Excludes1 — never code together — inherited from E70-E88

The conditions below can never be reported together with E88.3 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

  • androgen insensitivity syndrome (E34.5-)
  • congenital adrenal hyperplasia (E25.0)
  • hemolytic anemias attributable to enzyme disorders (D55.-)
  • Marfan syndrome (Q87.4-)
  • 5-alpha-reductase deficiency (E29.1)

Excludes1 — never code together — inherited from E88

The conditions below can never be reported together with E88.3 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

  • histiocytosis X (chronic) (C96.6)

Use additional code — inherited from E88

Report an additional code alongside E88.3 to fully describe the condition. E88.3 is sequenced first.

  • codes for associated conditions

Excludes2 — not included here — inherited from E70-E88

The conditions below are not part of E88.3, but a patient may have both at the same time. When documentation supports it, E88.3 and the excluded code may both be reported.

  • Ehlers-Danlos syndromes (Q79.6-)

How long has E88.3 existed?

E88.3 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.

What other codes are in the E88 family? (7)