ICD-10 Code for Sickle Cell Disease (SCD)
The ICD-10-CM code for sickle cell disease (SCD) is D57.1 — Sickle-cell disease without crisis. It is billable for FY2027.
Sickle cell disease ICD-10 codes at a glance
| Condition | Sickle cell disease (SCD) |
|---|---|
| Code | D57.1 — Sickle-cell disease without crisis |
| Billable | Yes (D57.1) |
| Alphabetic Index entry | Disease, diseased, sickle-cell |
| Code set | ICD-10-CM FY2027, valid October 1, 2026 – September 30, 2027 |
What changes the sickle cell disease code?
The Alphabetic Index lists these qualifiers under Disease, diseased, sickle-cell. If the record documents one of them, the code changes. Verify the code in the Tabular List before reporting it.
| with › acute chest syndrome | D57.01 | Hb-SS disease with acute chest syndrome |
| with › cerebral vascular involvement | D57.03 | Hb-SS disease with cerebral vascular involvement |
| with › crisis | D57.00 | Hb-SS disease with crisis, unspecified |
| with › dactylitis | D57.04 | Hb-SS disease with dactylitis |
| with › pain | D57.00 | Hb-SS disease with crisis, unspecified |
| with › priapism | D57.09 | Hb-SS disease with crisis with other specified complication |
| with › splenic sequestration | D57.02 | Hb-SS disease with splenic sequestration |
| elliptocytosis | D57.8- | Other sickle-cell disorders |
| Hb-C | D57.20 | Sickle-cell/Hb-C disease without crisis |
| Hb-C › without crisis | D57.20 | Sickle-cell/Hb-C disease without crisis |
| Hb-SD | D57.80 | Other sickle-cell disorders without crisis |
| Hb-SD › without crisis | D57.80 | Other sickle-cell disorders without crisis |
| Hb-SE | D57.80 | Other sickle-cell disorders without crisis |
| Hb-SE › without crisis | D57.80 | Other sickle-cell disorders without crisis |
| specified NEC | D57.80 | Other sickle-cell disorders without crisis |
| specified NEC › without crisis | D57.80 | Other sickle-cell disorders without crisis |
| spherocytosis | D57.80 | Other sickle-cell disorders without crisis |
| spherocytosis › without crisis | D57.80 | Other sickle-cell disorders without crisis |
| thalassemia | D57.40 | Sickle-cell thalassemia without crisis |
| thalassemia › beta plus | D57.44 | Sickle-cell thalassemia beta plus without crisis |
| thalassemia › beta zero | D57.42 | Sickle-cell thalassemia beta zero without crisis |
| thalassemia › without crisis | D57.40 | Sickle-cell thalassemia without crisis |
What else changes the sickle cell disease code?
The genotype changes the code family: Hb-SS disease is D57.0-/D57.1, Hb-SC disease is D57.2-, sickle-cell/beta-thalassemia is D57.4-, and other or unspecified combinations are D57.8-. Within each, a crisis is coded separately from the disease without crisis, and complications — acute chest syndrome, splenic sequestration, cerebral vascular involvement, dactylitis — are identified by their own 6th character. An additional code identifies any associated fever.
What does the Tabular List say about D57.1?
The instructional notes that govern D57.1, including those it inherits from its category and chapter. An Excludes1 note means the two codes are never reported together.
Inclusion terms
Alternative wording in documentation that is classified to D57.1.
- Hb-SS disease without crisis
- Sickle-cell anemia NOS
- Sickle-cell disease NOS
- Sickle-cell disorder NOS
Excludes1 — never code together — inherited from D57
The conditions below can never be reported together with D57.1 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- other hemoglobinopathies (D58.-)
Use additional code — inherited from D57
Report an additional code alongside D57.1 to fully describe the condition. D57.1 is sequenced first.
- code for any associated fever (R50.81)
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D57.1, but a patient may have both at the same time. When documentation supports it, D57.1 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Codes, descriptions and Index entries are from the official ICD-10-CM FY2027 release. Guideline text is quoted from the ICD-10-CM Official Guidelines for Coding and Reporting FY 2027. A code must always be verified in the Tabular List before it is reported. Data sources