ICD-10 Code for Hemoglobinopathy

Also indexed as (mixed)

The ICD-10-CM code for hemoglobinopathy is D58.2 — Other hemoglobinopathies. This is the code the Alphabetic Index gives for hemoglobinopathy with no further qualifier, valid for FY2027 (October 1, 2026 – September 30, 2027).

Billable

Which hemoglobinopathy code should you use?

The Alphabetic Index lists 10 codes under Hemoglobinopathy. Which one applies depends on the qualifier documented in the record — the type, site, cause, or associated condition. Find the qualifier below, then verify the code in the Tabular List before using it.

By type

with thalassemia	D56.8	Other thalassemias
sickle-cell	D57.1	Sickle-cell disease without crisis

Hemoglobinopathy sickle-cell

with thalassemia	D57.40	Sickle-cell thalassemia without crisis
with thalassemia › without crisis	D57.40	Sickle-cell thalassemia without crisis
with thalassemia › with › acute chest syndrome	D57.411	Sickle-cell thalassemia, unspecified, with acute chest syndrome
with thalassemia › with › cerebral vascular involvement	D57.413	Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
with thalassemia › with › crisis	D57.419	Sickle-cell thalassemia, unspecified, with crisis
with thalassemia › with › pain	D57.419	Sickle-cell thalassemia, unspecified, with crisis
with thalassemia › with › splenic sequestration	D57.412	Sickle-cell thalassemia, unspecified, with splenic sequestration
with thalassemia › with › crisis › with › dactylitis	D57.414	Sickle-cell thalassemia, unspecified, with dactylitis
with thalassemia › with › crisis › with › specified complication NEC	D57.418	Sickle-cell thalassemia, unspecified, with crisis with other specified complication

Index terms and codes are reproduced from the official ICD-10-CM FY2027 release. The Alphabetic Index is a finding aid — a code must always be verified in the Tabular List before it is reported. Data sources