D89 — Other disorders involving the immune mechanism, not elsewhere classified
Is D89 billable?
No — D89 is a non-billable header code. D89 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 24 billable codes beneath D89.
Billable codes under this header
- D89.0Polyclonal hypergammaglobulinemia
- D89.1Cryoglobulinemia
- D89.2Hypergammaglobulinemia, unspecified
- D89.3Immune reconstitution syndrome
- D89.9Disorder involving the immune mechanism, unspecified
- D89.40Mast cell activation, unspecified
- D89.41Monoclonal mast cell activation syndrome
- D89.42Idiopathic mast cell activation syndrome
- D89.43Secondary mast cell activation
- D89.44Hereditary alpha tryptasemia
- D89.49Other mast cell activation disorder
- D89.82Autoimmune lymphoproliferative syndrome [ALPS]
- D89.84IgG4-related disease
- D89.89Other specified disorders involving the immune mechanism, not elsewhere classified
- D89.810Acute graft-versus-host disease
- D89.811Chronic graft-versus-host disease
- D89.812Acute on chronic graft-versus-host disease
- D89.813Graft-versus-host disease, unspecified
- D89.831Cytokine release syndrome, grade 1
- D89.832Cytokine release syndrome, grade 2
- D89.833Cytokine release syndrome, grade 3
- D89.834Cytokine release syndrome, grade 4
- D89.835Cytokine release syndrome, grade 5
- D89.839Cytokine release syndrome, grade unspecified
D89 at a glance
| Code | D89 |
|---|---|
| Description | Other disorders involving the immune mechanism, not elsewhere classified |
| Billable | No — header code |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Excludes1 — never code together
The conditions below can never be reported together with D89 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes2 — not included here
The conditions below are not part of D89, but a patient may have both at the same time. When documentation supports it, D89 and the excluded code may both be reported.
- transplant failure and rejection (T86.-)
Excludes1 — never code together — inherited from D80-D89
The conditions below can never be reported together with D89 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D89, but a patient may have both at the same time. When documentation supports it, D89 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Excludes2 — not included here — inherited from D80-D89
The conditions below are not part of D89, but a patient may have both at the same time. When documentation supports it, D89 and the excluded code may both be reported.
- human immunodeficiency virus [HIV] disease (B20)
What codes fall under D89? (7)
- D89.0Polyclonal hypergammaglobulinemia
- D89.1Cryoglobulinemia
- D89.2Hypergammaglobulinemia, unspecified
- D89.3Immune reconstitution syndrome
- D89.4Mast cell activation syndrome and related disordersnot billable
- D89.8Other specified disorders involving the immune mechanism, not elsewhere classifiednot billable
- D89.9Disorder involving the immune mechanism, unspecified
How long has D89 existed?
D89 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
Which codes are confused with D89?
ICD-10-CM declares these codes mutually exclusive with D89 — exactly one of each pair can be correct for a given encounter.