D89.839 — Cytokine release syndrome, grade unspecified
Is D89.839 billable?
Yes, but D89.839 is an unspecified code. D89.839 is a valid, billable ICD-10-CM code for encounters from October 1, 2026 through September 30, 2027. However, D89.839 is an unspecified or catch-all code. Payers apply additional scrutiny to unspecified codes and many deny them when the medical record supports a more specific option, so check the documentation before selecting D89.839 — the more specific alternatives are listed below.
D89.839 at a glance
| Code | D89.839 |
|---|---|
| Description | Cytokine release syndrome, grade unspecified |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
What Medicare edits apply to D89.839?
The Medicare Code Editor screens inpatient claims before they are grouped. These edits name D89.839 directly.
CMS will reject this code as the principal diagnosis on an inpatient claim. It describes something other than the condition chiefly responsible for the admission.
Which MS-DRGs does D89.839 group to?
D89.839 sits in MDC 16 and helps define the logic of 3 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 814Reticuloendothelial and Immunity Disorders with MCCmedical
- 815Reticuloendothelial and Immunity Disorders with CCmedical
- 816Reticuloendothelial and Immunity Disorders without CC/MCCmedical
How is D89.839 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to D89.839. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Syndrome › cytokine release
Excludes1 — never code together — inherited from D80-D89
The conditions below can never be reported together with D89.839 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes1 — never code together — inherited from D89
The conditions below can never be reported together with D89.839 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Code first — inherited from D89.83
The underlying condition below must be sequenced before D89.839. D89.839 describes a manifestation and cannot be the principal or first-listed diagnosis.
Use additional code — inherited from D89.83
Report an additional code alongside D89.839 to fully describe the condition. D89.839 is sequenced first.
- code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
- code to identify associated manifestations
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D89.839, but a patient may have both at the same time. When documentation supports it, D89.839 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Excludes2 — not included here — inherited from D80-D89
The conditions below are not part of D89.839, but a patient may have both at the same time. When documentation supports it, D89.839 and the excluded code may both be reported.
- human immunodeficiency virus [HIV] disease (B20)
Excludes2 — not included here — inherited from D89
The conditions below are not part of D89.839, but a patient may have both at the same time. When documentation supports it, D89.839 and the excluded code may both be reported.
- transplant failure and rejection (T86.-)
How long has D89.839 existed?
D89.839 first appears in FY2021 (FY2020 is not available, so it may have appeared then).
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.