D89.4 — Mast cell activation syndrome and related disorders
Is D89.4 billable?
No — D89.4 is a non-billable header code. D89.4 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 6 billable codes beneath D89.4.
D89.4 at a glance
| Code | D89.4 |
|---|---|
| Description | Mast cell activation syndrome and related disorders |
| Billable | No — header code |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Excludes1 — never code together
The conditions below can never be reported together with D89.4 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- aggressive systemic mastocytosis (C96.21)
- congenital cutaneous mastocytosis (Q82.2)
- (non-congenital) cutaneous mastocytosis (D47.01)
- (indolent) systemic mastocytosis (D47.02)
- malignant mast cell neoplasm (C96.2-)
- malignant mastocytoma (C96.29)
- mast cell leukemia (C94.3-)
- mast cell sarcoma (C96.22)
- mastocytoma NOS (D47.09)
- other mast cell neoplasms of uncertain behavior (D47.09)
- systemic mastocytosis associated with a clonal hematologic non-mast cell lineage disease (SM-AHNMD) (D47.02)
Excludes1 — never code together — inherited from D80-D89
The conditions below can never be reported together with D89.4 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes1 — never code together — inherited from D89
The conditions below can never be reported together with D89.4 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D89.4, but a patient may have both at the same time. When documentation supports it, D89.4 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Excludes2 — not included here — inherited from D80-D89
The conditions below are not part of D89.4, but a patient may have both at the same time. When documentation supports it, D89.4 and the excluded code may both be reported.
- human immunodeficiency virus [HIV] disease (B20)
Excludes2 — not included here — inherited from D89
The conditions below are not part of D89.4, but a patient may have both at the same time. When documentation supports it, D89.4 and the excluded code may both be reported.
- transplant failure and rejection (T86.-)
What codes fall under D89.4? (6)
How long has D89.4 existed?
D89.4 first appears in FY2018 (FY2017 is not available, so it may have appeared then).
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
Which codes are confused with D89.4?
ICD-10-CM declares these codes mutually exclusive with D89.4 — exactly one of each pair can be correct for a given encounter.