E85.4 — Organ-limited amyloidosis
Is E85.4 billable?
Yes — E85.4 is billable for FY2027. E85.4 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. E85.4 may be submitted for encounters from October 1, 2026 through September 30, 2027.
E85.4 at a glance
| Code | E85.4 |
|---|---|
| Description | Organ-limited amyloidosis |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Which MS-DRGs does E85.4 group to?
E85.4 sits in MDC 08 and helps define the logic of 3 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 545Connective Tissue Disorders with MCCmedical
- 546Connective Tissue Disorders with CCmedical
- 547Connective Tissue Disorders without CC/MCCmedical
As a secondary diagnosis, E85.4 is a complication or comorbidity (CC), which can move a stay into a higher-paying DRG.
How is E85.4 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to E85.4. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Amyloid heart (disease)
- Amyloidosis › with lung involvement (generalized) (primary)
- Amyloidosis › heart (generalized) (primary)
- Amyloidosis › liver (generalized) (primary)
- Amyloidosis › localized (generalized) (primary)
- Amyloidosis › organ limited (generalized) (primary)
- Amyloidosis › pulmonary (generalized) (primary)
- Amyloidosis › skin (generalized) (primary)
- Amyloidosis › subglottic (generalized) (primary)
- Cardiomyopathy › amyloid (familial) (idiopathic)
- Cardiomyopathy › transthyretin-relatedfamilial amyloid (familial) (idiopathic)
- Degeneration, degenerative › intestine, amyloid
Inclusion terms
Alternative wording in documentation that is classified to E85.4.
- Localized amyloidosis
- Transthyretin-related (ATTR) familial amyloid cardiomyopathy
Excludes1 — never code together — inherited from Chapter 4
The conditions below can never be reported together with E85.4 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Excludes1 — never code together — inherited from E70-E88
The conditions below can never be reported together with E85.4 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes2 — not included here — inherited from E70-E88
The conditions below are not part of E85.4, but a patient may have both at the same time. When documentation supports it, E85.4 and the excluded code may both be reported.
- Ehlers-Danlos syndromes (Q79.6-)
Excludes2 — not included here — inherited from E85
The conditions below are not part of E85.4, but a patient may have both at the same time. When documentation supports it, E85.4 and the excluded code may both be reported.
- Alzheimer's disease (G30.0-)
How long has E85.4 existed?
E85.4 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.