C49 — Malignant neoplasm of other connective and soft tissue
Is C49 billable?
No — C49 is a non-billable header code. C49 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 20 billable codes beneath C49.
Billable codes under this header
- C49.0Malignant neoplasm of connective and soft tissue of head, face and neck
- C49.3Malignant neoplasm of connective and soft tissue of thorax
- C49.4Malignant neoplasm of connective and soft tissue of abdomen
- C49.5Malignant neoplasm of connective and soft tissue of pelvis
- C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified
- C49.8Malignant neoplasm of overlapping sites of connective and soft tissue
- C49.9Malignant neoplasm of connective and soft tissue, unspecified
- C49.10Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
- C49.11Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
- C49.12Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
- C49.20Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
- C49.21Malignant neoplasm of connective and soft tissue of right lower limb, including hip
- C49.22Malignant neoplasm of connective and soft tissue of left lower limb, including hip
- C49.A0Gastrointestinal stromal tumor, unspecified site
- C49.A1Gastrointestinal stromal tumor of esophagus
- C49.A2Gastrointestinal stromal tumor of stomach
- C49.A3Gastrointestinal stromal tumor of small intestine
- C49.A4Gastrointestinal stromal tumor of large intestine
- C49.A5Gastrointestinal stromal tumor of rectum
- C49.A9Gastrointestinal stromal tumor of other sites
C49 at a glance
| Code | C49 |
|---|---|
| Description | Malignant neoplasm of other connective and soft tissue |
| Billable | No — header code |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Excludes1 — never code together
The conditions below can never be reported together with C49 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes2 — not included here
The conditions below are not part of C49, but a patient may have both at the same time. When documentation supports it, C49 and the excluded code may both be reported.
- Kaposi's sarcoma of soft tissue (C46.1)
- malignant neoplasm of heart (C38.0)
- malignant neoplasm of peripheral nerves and autonomic nervous system (C47.-)
- malignant neoplasm of peritoneum (C48.2)
- malignant neoplasm of retroperitoneum (C48.0)
- malignant neoplasm of uterine ligament (C57.3)
- mesothelioma (C45.-)
Includes
Conditions classified to C49.
- malignant neoplasm of blood vessel
- malignant neoplasm of bursa
- malignant neoplasm of cartilage
- malignant neoplasm of fascia
- malignant neoplasm of fat
- malignant neoplasm of ligament, except uterine
- malignant neoplasm of lymphatic vessel
- malignant neoplasm of muscle
- malignant neoplasm of synovia
- malignant neoplasm of tendon (sheath)
What codes fall under C49? (10)
- C49.0Malignant neoplasm of connective and soft tissue of head, face and neck
- C49.1Malignant neoplasm of connective and soft tissue of upper limb, including shouldernot billable
- C49.2Malignant neoplasm of connective and soft tissue of lower limb, including hipnot billable
- C49.3Malignant neoplasm of connective and soft tissue of thorax
- C49.4Malignant neoplasm of connective and soft tissue of abdomen
- C49.5Malignant neoplasm of connective and soft tissue of pelvis
- C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified
- C49.8Malignant neoplasm of overlapping sites of connective and soft tissue
- C49.9Malignant neoplasm of connective and soft tissue, unspecified
- C49.AGastrointestinal stromal tumornot billable
How long has C49 existed?
C49 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
Which codes are confused with C49?
ICD-10-CM declares these codes mutually exclusive with C49 — exactly one of each pair can be correct for a given encounter.