Z16 — Resistance to antimicrobial drugs
Is Z16 billable?
No — Z16 is a non-billable header code. Z16 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 19 billable codes beneath Z16.
Billable codes under this header
- Z16.10Resistance to unspecified beta lactam antibiotics
- Z16.11Resistance to penicillins
- Z16.12Extended spectrum beta lactamase (ESBL) resistance
- Z16.13Resistance to carbapenem
- Z16.19Resistance to other specified beta lactam antibiotics
- Z16.20Resistance to unspecified antibiotic
- Z16.21Resistance to vancomycin
- Z16.22Resistance to vancomycin related antibiotics
- Z16.23Resistance to quinolones and fluoroquinolones
- Z16.24Resistance to multiple antibiotics
- Z16.29Resistance to other single specified antibiotic
- Z16.30Resistance to unspecified antimicrobial drugs
- Z16.31Resistance to antiparasitic drug(s)
- Z16.32Resistance to antifungal drug(s)
- Z16.33Resistance to antiviral drug(s)
- Z16.35Resistance to multiple antimicrobial drugs
- Z16.39Resistance to other specified antimicrobial drug
- Z16.341Resistance to single antimycobacterial drug
- Z16.342Resistance to multiple antimycobacterial drugs
Z16 at a glance
| Code | Z16 |
|---|---|
| Description | Resistance to antimicrobial drugs |
| Billable | No — header code |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Excludes1 — never code together
The conditions below can never be reported together with Z16 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Code first
The underlying condition below must be sequenced before Z16. Z16 describes a manifestation and cannot be the principal or first-listed diagnosis.
- the infection
Note
- The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.
What codes fall under Z16? (3)
How long has Z16 existed?
Z16 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.