Z16.3 — Resistance to other antimicrobial drugs

Not billable

Is Z16.3 billable?

No — Z16.3 is a non-billable header code. Z16.3 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 8 billable codes beneath Z16.3.

Billable codes under this header

Z16.3 at a glance

Code	Z16.3
Description	Resistance to other antimicrobial drugs
Billable	No — header code
Code set	ICD-10-CM FY2027
Valid for encounters	October 1, 2026 – September 30, 2027

Excludes1 — never code together

The conditions below can never be reported together with Z16.3 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

resistance to antibiotics (Z16.1-, Z16.2-)

Excludes1 — never code together — inherited from Z16

The conditions below can never be reported together with Z16.3 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

Methicillin resistant Staphylococcus aureus infection (A49.02)
Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code first — inherited from Z16

The underlying condition below must be sequenced before Z16.3. Z16.3 describes a manifestation and cannot be the principal or first-listed diagnosis.

the infection

What codes fall under Z16.3? (7)

How long has Z16.3 existed?

Z16.3 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.