D89.83 — Cytokine release syndrome
Is D89.83 billable?
No — D89.83 is a non-billable header code. D89.83 groups more specific codes and cannot be submitted on a claim. A valid ICD-10-CM code must be reported at the highest level of specificity available in its branch. Select one of the 6 billable codes beneath D89.83.
D89.83 at a glance
| Code | D89.83 |
|---|---|
| Description | Cytokine release syndrome |
| Billable | No — header code |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Code first
The underlying condition below must be sequenced before D89.83. D89.83 describes a manifestation and cannot be the principal or first-listed diagnosis.
Use additional code
Report an additional code alongside D89.83 to fully describe the condition. D89.83 is sequenced first.
- code for adverse effect, if applicable, to identify immune checkpoint inhibitors and immunostimulant drugs (T45.AX5)
- code to identify associated manifestations
Excludes1 — never code together — inherited from D80-D89
The conditions below can never be reported together with D89.83 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes1 — never code together — inherited from D89
The conditions below can never be reported together with D89.83 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D89.83, but a patient may have both at the same time. When documentation supports it, D89.83 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Excludes2 — not included here — inherited from D80-D89
The conditions below are not part of D89.83, but a patient may have both at the same time. When documentation supports it, D89.83 and the excluded code may both be reported.
- human immunodeficiency virus [HIV] disease (B20)
Excludes2 — not included here — inherited from D89
The conditions below are not part of D89.83, but a patient may have both at the same time. When documentation supports it, D89.83 and the excluded code may both be reported.
- transplant failure and rejection (T86.-)
What codes fall under D89.83? (6)
How long has D89.83 existed?
D89.83 first appears in FY2021 (FY2020 is not available, so it may have appeared then).
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.