C25.4 — Malignant neoplasm of endocrine pancreas

BillableCC

Is C25.4 billable?

Yes — C25.4 is billable for FY2027. C25.4 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. C25.4 may be submitted for encounters from October 1, 2026 through September 30, 2027.

C25.4 at a glance

Code	C25.4
Description	Malignant neoplasm of endocrine pancreas
Billable	Yes
Code set	ICD-10-CM FY2027
Valid for encounters	October 1, 2026 – September 30, 2027

Which MS-DRGs does C25.4 group to?

C25.4 sits in MDC 07 and helps define the logic of 3 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.

435Malignancy of Hepatobiliary System or Pancreas with MCCmedical
436Malignancy of Hepatobiliary System or Pancreas with CCmedical
437Malignancy of Hepatobiliary System or Pancreas without CC/MCCmedical

As a secondary diagnosis, C25.4 is a complication or comorbidity (CC), which can move a stay into a higher-paying DRG.

How is C25.4 listed in the Alphabetic Index?

These are the routes through the Alphabetic Index that lead to C25.4. They show the wording a clinician may have documented, which often differs from the Tabular description.

Adenocarcinoma › islet cell › pancreas
Adenocarcinoma › islet cell › unspecified site
Carcinoma › islet cell › pancreas (malignant)
Carcinoma › islet cell › unspecified site (malignant)
Gastrinoma › malignant › pancreas
Gastrinoma › malignant › unspecified site
Glucagonoma › pancreas › malignant
Glucagonoma › unspecified site › malignant
Insulinoma › pancreas › malignant
Insulinoma › unspecified site › malignant
Tumor › alpha-cell › malignant › pancreas
Tumor › alpha-cell › malignant › unspecified site

Use additional code

Report an additional code alongside C25.4 to fully describe the condition. C25.4 is sequenced first.

code to identify any functional activity.

Inclusion terms

Alternative wording in documentation that is classified to C25.4.

Malignant neoplasm of islets of Langerhans

Excludes1 — never code together — inherited from C15-C26

The conditions below can never be reported together with C25.4 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.

Kaposi's sarcoma of gastrointestinal sites (C46.4)

Use additional code — inherited from C25

Report an additional code alongside C25.4 to fully describe the condition. C25.4 is sequenced first.

code to identify:
alcohol abuse and dependence (F10.-)

Excludes2 — not included here — inherited from C15-C26

The conditions below are not part of C25.4, but a patient may have both at the same time. When documentation supports it, C25.4 and the excluded code may both be reported.

gastrointestinal stromal tumors (C49.A-)

Code also — inherited from C25

Two codes may be needed to describe the condition fully. Whether C25.4 is sequenced first depends on the reason for the encounter.

if applicable exocrine pancreatic insufficiency (K86.81)

How long has C25.4 existed?

C25.4 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.

Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.

Which codes are confused with C25.4?

ICD-10-CM declares these codes mutually exclusive with C25.4 — exactly one of each pair can be correct for a given encounter.

vs C75Malignant neoplasm of other endocrine glands and related structures