C25.4 vs C75
C25.4 and C75 can never be reported together. ICD-10-CM declares them mutually exclusive with an Excludes1 note, meaning the two conditions cannot occur in the same patient — so exactly one of them is correct for any given encounter.
The official note, declared on C75
malignant neoplasm of endocrine pancreas (C25.4)
C25.4
Malignant neoplasm of endocrine pancreas
Billable
- Chapter 2
- Neoplasms
- Section
- C15-C26
Use when the record says
- Malignant neoplasm of islets of Langerhans
Indexed under
- Adenocarcinoma › islet cell › pancreas
- Adenocarcinoma › islet cell › unspecified site
- Carcinoma › islet cell › pancreas (malignant)
- Carcinoma › islet cell › unspecified site (malignant)
- Gastrinoma › malignant › pancreas
C75
Malignant neoplasm of other endocrine glands and related structures
Not billable
- Chapter 2
- Neoplasms
- Section
- C73-C75
Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027