E75.3 vs E78
E75.3 and E78 can never be reported together. ICD-10-CM declares them mutually exclusive with an Excludes1 note, meaning the two conditions cannot occur in the same patient — so exactly one of them is correct for any given encounter.
The official note, declared on E78
sphingolipidosis (E75.0-E75.3)
E75.3
Sphingolipidosis, unspecified
BillableUnspecified
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E70-E88
Indexed under
- Sphingolipidosis
- Sphingomyelinosis
- Degeneration, degenerative › brain › in › sphingolipidosis
E78
Disorders of lipoprotein metabolism and other lipidemias
Not billable
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E70-E88
Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027