E22 vs E27.0
E22 and E27.0 can never be reported together. ICD-10-CM declares them mutually exclusive with an Excludes1 note, meaning the two conditions cannot occur in the same patient — so exactly one of them is correct for any given encounter.
The official note, declared on E22
overproduction of ACTH not associated with Cushing's disease (E27.0)
E22
Hyperfunction of pituitary gland
Not billable
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E20-E35
E27.0
Other adrenocortical overactivity
Billable
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E20-E35
Use when the record says
- Overproduction of ACTH, not associated with Cushing's disease
- Premature adrenarche
Indexed under
- Adrenarche, premature
- Schroeder's syndrome (endocrine hypertensive)
- Slocumb's syndrome
- Dysadrenocortism › hyperfunction
- Hyperadrenocorticism › not associated with Cushing's syndrome
Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027