FY2027
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Excludes1 pair

E22- vs E27.0

E22 and E27.0 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on E22
overproduction of ACTH not associated with Cushing's disease (E27.0)
E22

Hyperfunction of pituitary gland

Not billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
E27.0

Other adrenocortical overactivity

Billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
Use when the record says
  • Overproduction of ACTH, not associated with Cushing's disease
  • Premature adrenarche
Indexed under
  • Adrenarche, premature
  • Schroeder's syndrome (endocrine hypertensive)
  • Slocumb's syndrome
  • Dysadrenocortism › hyperfunction
  • Hyperadrenocorticism › not associated with Cushing's syndrome

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027