E22 vs E24.0
E22 and E24.0 can never be reported together. ICD-10-CM declares them mutually exclusive with an Excludes1 note, meaning the two conditions cannot occur in the same patient — so exactly one of them is correct for any given encounter.
The official note, declared on E22
overproduction of pituitary ACTH (E24.0)
E22
Hyperfunction of pituitary gland
Not billable
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E20-E35
E24.0
Pituitary-dependent Cushing's disease
Billable
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E20-E35
Use when the record says
- Overproduction of pituitary ACTH
- Pituitary-dependent hypercorticalism
Indexed under
- Basophilism (cortico-adrenal) (Cushing's) (pituitary)
- Hypercorticalism, pituitary-dependent
- Hyperadrenocorticism › pituitary-dependent
- Cushing's › syndrome or disease › pituitary-dependent
- Hypersecretion › ACTH › pituitary
Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027