ICD-10 Code for Immunodeficiency

The ICD-10-CM code for immunodeficiency is D84.9 — Immunodeficiency, unspecified. This is the code the Alphabetic Index gives for immunodeficiency with no further qualifier, valid for FY2027 (October 1, 2026 – September 30, 2027).

BillableUnspecified

D84.9 is billable but unspecified. If the documentation names a type, site or cause, one of the more specific codes below is likely expected.

Which immunodeficiency code should you use?

The Alphabetic Index lists 33 codes under Immunodeficiency. Which one applies depends on the qualifier documented in the record — the type, site, cause, or associated condition. Find the qualifier below, then verify the code in the Tabular List before using it.

By type

autosomal recessive, Swiss type	D80.0	Hereditary hypogammaglobulinemia
combined	D81.9	Combined immunodeficiency, unspecified
common variable	D83.9	Common variable immunodeficiency, unspecified
following hereditary defective response to Epstein-Barr virus	D82.3	Immunodeficiency following hereditary defective response to Epstein-Barr virus
severe combined	D81.9	Combined immunodeficiency, unspecified
specified type NEC	D84.89	Other immunodeficiencies
X-linked, with increased IgM	D80.5	Immunodeficiency with increased immunoglobulin M [IgM]

Immunodeficiency with

adenosine-deaminase deficiency	D81.30	Adenosine deaminase deficiency, unspecified
antibody defects	D80.9	Immunodeficiency with predominantly antibody defects, unspecified
hyperimmunoglobulinemia	D80.6	Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
increased immunoglobulin M	D80.5	Immunodeficiency with increased immunoglobulin M [IgM]
major defect	D82.9	Immunodeficiency associated with major defect, unspecified
partial albinism	D82.8	Immunodeficiency associated with other specified major defects
short-limbed stature	D82.2	Immunodeficiency with short-limbed stature
thrombocytopenia and eczema	D82.0	Wiskott-Aldrich syndrome
antibody defects › specified type NEC	D80.8	Other immunodeficiencies with predominantly antibody defects
major defect › specified type NEC	D82.8	Immunodeficiency associated with other specified major defects

Immunodeficiency antibody with

hyperimmunoglobulinemia	D80.6	Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia
near-normal immunoglobulins	D80.6	Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemia

Immunodeficiency combined

biotin-dependent carboxylase	D81.819	Biotin-dependent carboxylase deficiency, unspecified
severe	D81.9	Combined immunodeficiency, unspecified
specified type NEC	D81.89	Other combined immunodeficiencies
biotin-dependent carboxylase › biotinidase	D81.810	Biotinidase deficiency
biotin-dependent carboxylase › holocarboxylase synthetase	D81.818	Other biotin-dependent carboxylase deficiency
biotin-dependent carboxylase › specified type NEC	D81.818	Other biotin-dependent carboxylase deficiency
severe › with › low or normal B-cell numbers	D81.2	Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
severe › with › low T- and B-cell numbers	D81.1	Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
severe › with › reticular dysgenesis	D81.0	Severe combined immunodeficiency [SCID] with reticular dysgenesis

Immunodeficiency common variable

specified type NEC	D83.8	Other common variable immunodeficiencies
with › abnormalities of B-cell numbers and function	D83.0	Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
with › autoantibodies to B- or T-cells	D83.2	Common variable immunodeficiency with autoantibodies to B- or T-cells
with › immunoregulatory T-cell disorders	D83.1	Common variable immunodeficiency with predominant immunoregulatory T-cell disorders

Immunodeficiency due to

conditions classified elsewhere	D84.81	Immunodeficiency due to conditions classified elsewhere
drugs	D84.821	Immunodeficiency due to drugs
external causes	D84.822	Immunodeficiency due to external causes
medication	D84.821	Immunodeficiency due to drugs

Immunodeficiency selective, immunoglobulin

A	D80.2	Selective deficiency of immunoglobulin A [IgA]
G	D80.3	Selective deficiency of immunoglobulin G [IgG] subclasses
M	D80.4	Selective deficiency of immunoglobulin M [IgM]

Immunodeficiency severe combined

due to adenosine deaminase deficiency

D81.31

Severe combined immunodeficiency due to adenosine deaminase deficiency

Index terms and codes are reproduced from the official ICD-10-CM FY2027 release. The Alphabetic Index is a finding aid — a code must always be verified in the Tabular List before it is reported. Data sources