D59.4 — Other nonautoimmune hemolytic anemias
Is D59.4 billable?
Yes — D59.4 is billable for FY2027. D59.4 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. D59.4 may be submitted for encounters from October 1, 2026 through September 30, 2027.
D59.4 at a glance
| Code | D59.4 |
|---|---|
| Description | Other nonautoimmune hemolytic anemias |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Which MS-DRGs does D59.4 group to?
D59.4 sits in MDC 15 and helps define the logic of 1 MS-DRG (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 791Prematurity with Major Problemsmedical
As a secondary diagnosis, D59.4 is a complication or comorbidity (CC), which can move a stay into a higher-paying DRG.
How is D59.4 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to D59.4. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Nonautoimmune hemolytic anemia
- Disease, diseased › nonautoimmune hemolytic
- Syndrome › erythrocyte fragmentation
- Anemia › hemolytic › mechanical (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › hemolytic › microangiopathic (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › hemolytic › nonautoimmune (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › hemolytic › secondary (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › hemolytic › symptomatic (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › hemolytic › toxic (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › hemolytic › acquired › infectious (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › hemolytic › acquired › toxic (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › hemolytic › due to › cardiac conditions (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
Inclusion terms
Alternative wording in documentation that is classified to D59.4.
- Mechanical hemolytic anemia
- Microangiopathic hemolytic anemia
- Toxic hemolytic anemia
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D59.4, but a patient may have both at the same time. When documentation supports it, D59.4 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
How long has D59.4 existed?
D59.4 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
Which conditions are coded to D59.4?
What other codes are in the D59 family? (8)
- D59.0Drug-induced autoimmune hemolytic anemia
- D59.1Other autoimmune hemolytic anemiasnot billable
- D59.2Drug-induced nonautoimmune hemolytic anemia
- D59.3Hemolytic-uremic syndromenot billable
- D59.5Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
- D59.6Hemoglobinuria due to hemolysis from other external causes
- D59.8Other acquired hemolytic anemias
- D59.9Acquired hemolytic anemia, unspecified