D53.0 — Protein deficiency anemia
Is D53.0 billable?
Yes — D53.0 is billable for FY2027. D53.0 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. D53.0 may be submitted for encounters from October 1, 2026 through September 30, 2027.
D53.0 at a glance
| Code | D53.0 |
|---|---|
| Description | Protein deficiency anemia |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Which MS-DRGs does D53.0 group to?
D53.0 sits in MDC 16 and helps define the logic of 2 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 811Red Blood Cell Disorders with MCCmedical
- 812Red Blood Cell Disorders without MCCmedical
How is D53.0 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to D53.0. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Amino-acid disorder › anemia
- Anemia › amino-acid-deficiency (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › orotaciduric (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › protein-deficiency (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Orotaciduria, oroticaciduria › anemia (congenital) (hereditary) (pyrimidine deficiency)
- Aciduria › orotic › anemia
- Anemia › deficiency › amino-acid (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › deficiency › protein (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › megaloblastic › orotic aciduria (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Deficiency, deficient › protein › anemia
- Anemia › due to › deficiency › amino-acid (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
- Anemia › due to › deficiency › protein (essential) (general) (hemoglobin deficiency) (infantile) (primary) (profound)
Excludes1 — never code together
The conditions below can never be reported together with D53.0 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- Lesch-Nyhan syndrome (E79.1)
Inclusion terms
Alternative wording in documentation that is classified to D53.0.
- Amino-acid deficiency anemia
- Orotaciduric anemia
Excludes2 — not included here — inherited from Chapter 3
The conditions below are not part of D53.0, but a patient may have both at the same time. When documentation supports it, D53.0 and the excluded code may both be reported.
- autoimmune disease (systemic) NOS (M35.9)
- certain conditions originating in the perinatal period (P00-P96)
- complications of pregnancy, childbirth and the puerperium (O00-O9A)
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
- endocrine, nutritional and metabolic diseases (E00-E88)
- human immunodeficiency virus [HIV] disease (B20)
- injury, poisoning and certain other consequences of external causes (S00-T88)
- neoplasms (C00-D49)
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
How long has D53.0 existed?
D53.0 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
Which codes are confused with D53.0?
ICD-10-CM declares these codes mutually exclusive with D53.0 — exactly one of each pair can be correct for a given encounter.