Excludes1 pair

T78.3- vs T80-

T78.3 and T80 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on T78.3
serum urticaria (T80.6-)
T78.3

Angioneurotic edema

Not billable
Chapter 19
Injury, poisoning and certain other consequences of external causes
Section
T66-T78
Use when the record says
  • Allergic angioedema
  • Giant urticaria
  • Quincke's edema
Indexed under
  • Angioedema (allergic) (any site) (with urticaria)
  • Angioneurotic edema (allergic) (any site) (with urticaria)
  • Bannister's disease
  • Quincke's disease or edema
  • Allergy, allergic › angioneurotic edema
T80

Complications following infusion, transfusion and therapeutic injection

Not billable
Chapter 19
Injury, poisoning and certain other consequences of external causes
Section
T80-T88
Use when the record says
  • complications following perfusion

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027