E80.5 vs P57.8
E80.5 and P57.8 can never be reported together. ICD-10-CM declares them mutually exclusive with an Excludes1 note, meaning the two conditions cannot occur in the same patient — so exactly one of them is correct for any given encounter.
The official note, declared on P57.8
Crigler-Najjar syndrome (E80.5)
E80.5
Crigler-Najjar syndrome
Billable
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E70-E88
Indexed under
- Crigler-Najjar disease or syndrome
- Deficiency, deficient › glucuronyl transferase
- Jaundice › familial nonhemolytic › Crigler-Najjar (yellow)
- Jaundice › newborn › due to or associated with › Crigler-Najjar syndrome (yellow)
P57.8
Other specified kernicterus
BillableUnspecified
- Chapter 16
- Certain conditions originating in the perinatal period
- Section
- P50-P61
Indexed under
- Kernicterus of newborn › specified type NEC (not due to isoimmunization)
These two codes sit in different chapters of the Tabular List, which is usually the clearest signal that they describe different underlying processes rather than different degrees of the same one.
Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027