Excludes1 pair

E50.5 vs H53.0-

E50.5 and H53.0 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on H53.0
amblyopia due to vitamin A deficiency (E50.5)
E50.5

Vitamin A deficiency with night blindness

Billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E50-E64
Indexed under
  • Hemeralopia › vitamin A deficiency
  • Amblyopia › nocturnal › vitamin A deficiency
  • Blindness › night › vitamin A deficiency
  • Deficiency, deficient › vitamin NOS › A › with › night blindness
H53.0

Amblyopia ex anopsia

Not billable
Chapter 7
Diseases of the eye and adnexa
Section
H53-H54

These two codes sit in different chapters of the Tabular List, which is usually the clearest signal that they describe different underlying processes rather than different degrees of the same one.

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027