Excludes1 pair

E27.1 vs E85-

E27.1 and E85 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on E27.1
amyloidosis (E85.-)
E27.1

Primary adrenocortical insufficiency

Billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
Use when the record says
  • Addison's disease
  • Autoimmune adrenalitis
Indexed under
  • Addison's › disease or syndrome (bronze)
  • Adrenalitis, adrenitis › autoimmune
  • Disease, diseased › bronze Addison's
  • Hypoadrenalism, hypoadrenia › primary
  • Hypoadrenocorticism › primary
E85

Amyloidosis

Not billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E70-E88

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027