Excludes1 pair

E24- vs E25.0

E24 and E25.0 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on E24
congenital adrenal hyperplasia (E25.0)
E24

Cushing's syndrome

Not billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
E25.0

Congenital adrenogenital disorders associated with enzyme deficiency

Billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
Use when the record says
  • Congenital adrenal hyperplasia
  • 21-Hydroxylase deficiency
  • Salt-losing congenital adrenal hyperplasia
Indexed under
  • Adrenogenitalism, congenital
  • Adrenogenital syndrome › congenital
  • Adrenogenital syndrome › salt loss
  • Defect, defective › 3-beta-hydroxysteroid dehydrogenase
  • Defect, defective › 11-hydroxylase

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027