Excludes1 pair

E24.3 vs E34.2

E24.3 and E34.2 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on E34.2
ectopic ACTH syndrome (E24.3)
E24.3

Ectopic ACTH syndrome

Billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
Indexed under
  • ACTH ectopic syndrome
  • Ectopic, ectopia › ACTH syndrome
  • Syndrome › ectopic ACTH
  • Syndrome › Cushing's › due to › ectopic ACTH
E34.2

Ectopic hormone secretion, not elsewhere classified

BillableUnspecified
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
Indexed under
  • Ectopic, ectopia › hormone secretion NEC
  • Secretion › hormone › ectopic NEC

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027