FY2027
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Excludes1 pair

E22.8 vs E30.1

E22.8 and E30.1 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on E30.1
central precocious puberty (E22.8)
E22.8

Other hyperfunction of pituitary gland

Billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
Use when the record says
  • Central precocious puberty
Indexed under
  • Hyperfunction › pituitary › specified NEC
  • Precocious › puberty › central
  • Puberty › precocious › central
  • Puberty › premature › due to › pituitary hyperfunction (anterior)
E30.1

Precocious puberty

Billable
Chapter 4
Endocrine, nutritional and metabolic diseases
Section
E20-E35
Use when the record says
  • Precocious menstruation
Indexed under
  • Precocity, sexual (constitutional) (cryptogenic) (female) (idiopathic) (male)
  • Pubarche, precocious
  • Pubertas praecox
  • Breast › buds
  • Buds › breast

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027