Excludes1 pair
E16.8 vs E22.0
E16.8 and E22.0 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.
The official note, declared on E22.0
increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
E16.8
Other specified disorders of pancreatic internal secretion
BillableUnspecified
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E15-E16
Use when the record says
- Increased secretion from endocrine pancreas of growth hormone-releasing hormone
- Increased secretion from endocrine pancreas of pancreatic polypeptide
- Increased secretion from endocrine pancreas of somatostatin
- Increased secretion from endocrine pancreas of vasoactive-intestinal polypeptide
Indexed under
- Disorder › pancreatic internal secretion › specified NEC
- Hyperplasia, hyperplastic › pancreatic islet cells › alpha
- Increase, increased › secretion › pancreas, endocrine › growth hormone-releasing hormone
- Increase, increased › secretion › pancreas, endocrine › pancreatic polypeptide
- Increase, increased › secretion › pancreas, endocrine › somatostatin
E22.0
Acromegaly and pituitary gigantism
Billable
- Chapter 4
- Endocrine, nutritional and metabolic diseases
- Section
- E20-E35
Use when the record says
- Overproduction of growth hormone
Indexed under
- Acromegaly, acromegalia
- Erdheim's syndrome (acromegalic macrospondylitis)
- Gigantism (cerebral) (hypophyseal) (pituitary)
- Launois' syndrome (pituitary gigantism)
- Macrospondylitis , acromegalic
Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027