Excludes1 pair

D46.9 vs D72-

D46.9 and D72 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on D72
preleukemia (syndrome) (D46.9)
D46.9

Myelodysplastic syndrome, unspecified

BillableUnspecified
Chapter 2
Neoplasms
Section
D37-D48
Use when the record says
  • Myelodysplasia NOS
Indexed under
  • Myelodysplasia
  • Myelodysplastic syndrome
  • Preleukemia (syndrome)
  • Anemia › myelodysplastic
  • Syndrome › myelodysplastic
D72

Other disorders of white blood cells

Not billable
Chapter 3
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Section
D70-D77

These two codes sit in different chapters of the Tabular List, which is usually the clearest signal that they describe different underlying processes rather than different degrees of the same one.

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027