Excludes1 pair

C81- vs C81.4-

C81 and C81.4 are not coded together. ICD-10-CM declares them mutually exclusive with an Excludes1 note — the two conditions are not expected to occur together, so exactly one of them is normally correct for a given encounter. The Official Guidelines carve out one exception: if the two conditions are clearly unrelated to each other, both may be reported.

The official note, declared on C81.4
nodular lymphocyte predominant Hodgkin lymphoma (C81.0-)
C81

Hodgkin lymphoma

Not billable
Chapter 2
Neoplasms
Section
C81-C96
C81.4

Lymphocyte-rich Hodgkin lymphoma

Not billable
Chapter 2
Neoplasms
Section
C81-C96
Use when the record says
  • Lymphocyte-rich classical Hodgkin lymphoma
Indexed under
  • Lymphoma › Hodgkin › lymphocyte-rich (classical)
  • Lymphoma › Hodgkin › lymphocyte-rich classical

Excludes1 is not always absolute: where two conditions covered by the note are genuinely unrelated, CMS guidance permits reporting both. Document the reasoning rather than assuming it. More on Excludes1 vs Excludes2 · FY2027