Z92.21 — Personal history of antineoplastic chemotherapy
Is Z92.21 billable?
Yes — Z92.21 is billable for FY2027. Z92.21 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. Z92.21 may be submitted for encounters from October 1, 2026 through September 30, 2027.
Z92.21 at a glance
| Code | Z92.21 |
|---|---|
| Description | Personal history of antineoplastic chemotherapy |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
What Medicare edits apply to Z92.21?
The Medicare Code Editor screens inpatient claims before they are grouped. These edits name Z92.21 directly.
CMS will reject this code as the principal diagnosis on an inpatient claim. It describes something other than the condition chiefly responsible for the admission.
Which MS-DRGs does Z92.21 group to?
Z92.21 sits in MDC 23 and helps define the logic of 2 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 949Aftercare with CC/MCCmedical
- 950Aftercare without CC/MCCmedical
How is Z92.21 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to Z92.21. They show the wording a clinician may have documented, which often differs from the Tabular description.
- History › personal › chemotherapy for neoplastic condition
- History › personal › drug therapy › antineoplastic chemotherapy
Excludes2 — not included here — inherited from Z92
The conditions below are not part of Z92.21, but a patient may have both at the same time. When documentation supports it, Z92.21 and the excluded code may both be reported.
- postprocedural states (Z98.-)
Excludes2 — not included here — inherited from Z92.2
The conditions below are not part of Z92.21, but a patient may have both at the same time. When documentation supports it, Z92.21 and the excluded code may both be reported.
- long term (current) drug therapy (Z79.-)
Code also — inherited from Z77-Z99
Two codes may be needed to describe the condition fully. Whether Z92.21 is sequenced first depends on the reason for the encounter.
- any follow-up examination (Z08-Z09)
How long has Z92.21 existed?
Z92.21 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
What other codes are in the Z92.2 family? (6)
- Z92.22Personal history of monoclonal drug therapy
- Z92.23Personal history of estrogen therapy
- Z92.24Personal history of steroid therapynot billable
- Z92.25Personal history of immunosuppression therapy
- Z92.26Personal history of immune checkpoint inhibitor therapy
- Z92.29Personal history of other drug therapy