E34.321 — Primary insulin-like growth factor-1 (IGF-1) deficiency
Is E34.321 billable?
Yes — E34.321 is billable for FY2027. E34.321 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. E34.321 may be submitted for encounters from October 1, 2026 through September 30, 2027.
E34.321 at a glance
| Code | E34.321 |
|---|---|
| Description | Primary insulin-like growth factor-1 (IGF-1) deficiency |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Which MS-DRGs does E34.321 group to?
E34.321 sits in MDC 10 and helps define the logic of 3 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 643Endocrine Disorders with MCCmedical
- 644Endocrine Disorders with CCmedical
- 645Endocrine Disorders without CC/MCCmedical
How is E34.321 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to E34.321. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Dwarfism › Laron-type
- Short, shortening, shortness › statureNEC › Laron-type
- Short, shortening, shortness › statureNEC › due to › genetic causes › acid-labile subunit genedefect
- Short, shortening, shortness › statureNEC › due to › genetic causes › growth hormone gene 1defect with growth hormone neutralizing antibodies
- Short, shortening, shortness › statureNEC › due to › genetic causes › growth hormone insensitivity syndrome
- Short, shortening, shortness › statureNEC › due to › genetic causes › insulin-like growth factor 1 genedefect
- Short, shortening, shortness › statureNEC › due to › genetic causes › primary insulin-like growth factor-1deficiency
- Short, shortening, shortness › statureNEC › due to › genetic causes › severe primary insulin-like growth factor-1 deficiency
- Short, shortening, shortness › statureNEC › due to › genetic causes › signal transducer and activator of transcription 5B genedefect
Inclusion terms
Alternative wording in documentation that is classified to E34.321.
- Acid-labile subunit gene (IGFALS) defect
- Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Growth hormone insensitivity syndrome (GHIS)
- Insulin-like growth factor 1 gene (IGF1) defect
- Laron type short stature
- Severe primary insulin-like growth factor-1 deficiency (SPIGFD)
- Signal transducer and activator of transcription 5B gene (STAT5b) defect
Excludes1 — never code together — inherited from Chapter 4
The conditions below can never be reported together with E34.321 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Excludes1 — never code together — inherited from E20-E35
The conditions below can never be reported together with E34.321 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
Excludes1 — never code together — inherited from E34
The conditions below can never be reported together with E34.321 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- pseudohypoparathyroidism (E20.1)
Excludes1 — never code together — inherited from E34.3
The conditions below can never be reported together with E34.321 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- achondroplastic short stature (Q77.4)
- hypochondroplastic short stature (Q77.4)
- nutritional short stature (E45)
- pituitary short stature (E23.0)
- progeria (E34.8)
- renal short stature (N25.0)
- Russell-Silver syndrome (Q87.19)
- short-limbed stature with immunodeficiency (D82.2)
- short stature (child) (R62.52)
- short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical Index
- short stature NOS (R62.52)
How long has E34.321 existed?
E34.321 first appears in FY2023.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.