E16.4 — Increased secretion of gastrin
Is E16.4 billable?
Yes — E16.4 is billable for FY2027. E16.4 is a valid, billable ICD-10-CM code at the highest level of specificity in its branch. E16.4 may be submitted for encounters from October 1, 2026 through September 30, 2027.
E16.4 at a glance
| Code | E16.4 |
|---|---|
| Description | Increased secretion of gastrin |
| Billable | Yes |
| Code set | ICD-10-CM FY2027 |
| Valid for encounters | October 1, 2026 – September 30, 2027 |
Which MS-DRGs does E16.4 group to?
E16.4 sits in MDC 06 and helps define the logic of 3 MS-DRGs (version 44, FY2027). Which one a stay actually groups to also depends on procedures and secondary diagnoses.
- 380Complicated Peptic Ulcer with MCCmedical
- 381Complicated Peptic Ulcer with CCmedical
- 382Complicated Peptic Ulcer without CC/MCCmedical
How is E16.4 listed in the Alphabetic Index?
These are the routes through the Alphabetic Index that lead to E16.4. They show the wording a clinician may have documented, which often differs from the Tabular description.
- Ellison-Zollinger syndrome
- Hypergastrinemia
- Zollinger-Ellison syndrome
- Abnormal, abnormality, abnormalities › gastrin secretion
- Hypersecretion › gastrin
- Abnormal, abnormality, abnormalities › secretion › gastrin
- Increase, increased › secretion › gastrin
- Hyperplasia, hyperplastic › pancreatic islet cells › alpha › with excess › gastrin
Inclusion terms
Alternative wording in documentation that is classified to E16.4.
- Hypergastrinemia
- Hyperplasia of pancreatic endocrine cells with gastrin excess
- Zollinger-Ellison syndrome
Excludes1 — never code together — inherited from Chapter 4
The conditions below can never be reported together with E16.4 on the same claim. An Excludes1 note means the two conditions cannot occur in the same patient, so reporting both is a coding error.
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)
How long has E16.4 existed?
E16.4 has been in ICD-10-CM since at least FY2016, the earliest fiscal year on record here.
Derived from the official order files for FY2016–FY2026. FY2017 and FY2020 publish no order file, so those years are not covered.
Which codes are confused with E16.4?
ICD-10-CM declares these codes mutually exclusive with E16.4 — exactly one of each pair can be correct for a given encounter.